Open AccessDynamics of Adaptive Microevolution of HypermutablePseudomonas aeruginosaduring Chronic Pulmonary Infection in Patients with Cystic Fibrosis
Author(s) -
Christina Hoboth,
Reinhard Hoffmann,
Anja Eichner,
Christine Henke,
Sabine Schmoldt,
Axel Imhof,
Jürgen Heesemann,
Michael Hogardt
Publication year - 2009
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/599360
Subject(s) - biology , pseudomonas aeruginosa , microbiology and biotechnology , transcriptome , virulence , cystic fibrosis , gene , gene expression , biochemistry , genetics , bacteria
In patients with cystic fibrosis (CF), the emergence of hypermutable Pseudomonas aeruginosa drives the selection of P. aeruginosa variants that are efficiently adapted to the inflamed lungs of these patients.
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