Chemotherapy Treatment in Pediatric Patients with Acute Myeloid Leukemia Receiving Antimicrobial Prophylaxis Leads to a Relative Increase of Colonization with Potentially Pathogenic Bacteria in the Gut | Zendy

Michel J. van Vliet | Zendy; Wim J. E. Tissing | Zendy; Catharina A. J. Dun | Zendy; Nico E. L. Meessen | Zendy; Willem A. Kamps | Zendy; Eveline S.J.M. de Bont | Zendy; Hermie J. M. Harmsen | Zendy

Open Access

Chemotherapy Treatment in Pediatric Patients with Acute Myeloid Leukemia Receiving Antimicrobial Prophylaxis Leads to a Relative Increase of Colonization with Potentially Pathogenic Bacteria in the Gut

Author(s) -

Michel J. van Vliet,

Wim J. E. Tissing,

Catharina A. J. Dun,

Nico E. L. Meessen,

Willem A. Kamps,

Eveline S.J.M. de Bont,

Hermie J. M. Harmsen

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/599346

Subject(s) - antibiotics , microbiology and biotechnology , antimicrobial , myeloid leukemia , feces , anaerobic bacteria , chemotherapy , medicine , bacteria , mucositis , colonization , biology , pathogenic bacteria , antimicrobial chemotherapy , immunology , genetics

Normally, humans are protected against infections by their anaerobic intestinal microorganisms providing colonization resistance. In immunocompromised patients, the endogenous intestinal gram-positive and gram-negative pathogens often cause infectious complications. Therefore, we analyzed the effect of chemotherapy treatment and antimicrobial prophylaxis on intestinal bacterial populations (microbiota) among pediatric patients with acute myeloid leukemia who are prone to intestinal mucositis and infections.

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