The SaeR/S Gene Regulatory System Is Essential for Innate Immune Evasion byStaphylococcus aureus | Zendy

Jovanka M. Voyich | Zendy; Cuong Vuong | Zendy; Mark DeWald | Zendy; Tyler K. Nygaard | Zendy; Stanislava Kocianova | Zendy; Shan Griffith | Zendy; Jennifer M. Jones | Zendy; Courtney Iverson | Zendy; Daniel E. Sturdevant | Zendy; Kevin R. Braughton | Zendy; Adeline R. Whitney | Zendy; Michaël Otto | Zendy; Frank R. DeLeo | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The SaeR/S Gene Regulatory System Is Essential for Innate Immune Evasion byStaphylococcus aureus

Author(s) -

Jovanka M. Voyich,

Cuong Vuong,

Mark DeWald,

Tyler K. Nygaard,

Stanislava Kocianova,

Shan Griffith,

Jennifer M. Jones,

Courtney Iverson,

Daniel E. Sturdevant,

Kevin R. Braughton,

Adeline R. Whitney,

Michaël Otto,

Frank R. DeLeo

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/598967

Subject(s) - staphylococcus aureus , virulence , innate immune system , biology , microbiology and biotechnology , pathogenesis , phagocytosis , gene , sepsis , evasion (ethics) , immune system , staphylococcal infections , virulence factor , pathogen , microarray , immunology , gene expression , bacteria , genetics

Methicillin-resistant Staphylococcus aureus is problematic both in hospitals and in the community. Currently, we have limited understanding of mechanisms of innate immune evasion used by S. aureus. To that end, we created an isogenic deletion mutant in strain MW2 (USA400) of the saeR/S 2-component gene regulatory system and studied its role in mouse models of pathogenesis and during human neutrophil interaction. In this study, we demonstrate that saeR/S plays a distinct role in S. aureus pathogenesis and is vital for virulence of MW2 in a mouse model of sepsis. Moreover, deletion of saeR/S significantly impaired survival of MW2 in human blood and after neutrophil phagocytosis. Microarray analysis revealed that SaeR/S of MW2 influences expression of a wide variety of genes with diverse biological functions. These data provide new insight into how virulence is regulated in S. aureus and associates a specific staphylococcal gene-regulatory system with invasive staphylococcal disease.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research