RecurrentBurkholderiaInfection in Patients with Chronic Granulomatous Disease: 11‐Year Experience at a Large Referral Center | Zendy

David E. Greenberg | Zendy; Joanna B. Goldberg | Zendy; Frida Stock | Zendy; Patrick R. Murray | Zendy; Steven M. Holland | Zendy; John J. LiPuma | Zendy

Open Access

RecurrentBurkholderiaInfection in Patients with Chronic Granulomatous Disease: 11‐Year Experience at a Large Referral Center

Author(s) -

David E. Greenberg,

Joanna B. Goldberg,

Frida Stock,

Patrick R. Murray,

Steven M. Holland,

John J. LiPuma

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/598937

Subject(s) - chronic granulomatous disease , burkholderia , burkholderia cepacia complex , medicine , polymerase chain reaction , genotyping , chronic infection , epidemiology , granulomatous disease , immunology , disease , microbiology and biotechnology , pathology , genotype , biology , bacteria , gene , genetics , immune system , biochemistry

The epidemiology of Burkholderia infection in persons with chronic granulomatous disease is poorly understood. We used species-specific polymerase chain reaction-based assays and genotyping analyses to identify 32 strains representing 9 Burkholderia species among 50 isolates recovered from 18 patients with chronic granulomatous disease. We found that recurrent pulmonary infection with distinct Burkholderia strains is common in chronic granulomatous disease.

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