Evaluation of Cellular Immunity to Mumps in Vaccinated Individuals with or without Circulating Antibodies up to 16 Years after Their Last Vaccination | Zendy

Corinne Vandermeulen | Zendy; Frédéric Clement | Zendy; Mathieu Roelants | Zendy; Pierre Van Damme | Zendy; Karel Hoppenbrouwers | Zendy; G LEROUXROELS | Zendy

Open Access

Evaluation of Cellular Immunity to Mumps in Vaccinated Individuals with or without Circulating Antibodies up to 16 Years after Their Last Vaccination

Author(s) -

Corinne Vandermeulen,

Frédéric Clement,

Mathieu Roelants,

Pierre Van Damme,

Karel Hoppenbrouwers,

G LEROUXROELS

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/598482

Subject(s) - medicine , antibody titer , immunology , antibody , vaccination , immunity , titer , cellular immunity , mumps vaccine , virology , immune system , immunization , measles vaccine

In this observational study, mumps-specific in vitro lymphoproliferation was measured in 24 subjects with low antibody titers and 24 subjects with high antibody titers who received their last vaccine dose up to 16 years previously. Overall, a significant lymphoproliferative response was found in 32 subjects (66.7%)-namely, in 13 (54.2%) of those with low antibody titers and 19 (79.2%) of those with high antibody titers. The mean stimulation index for subjects with low antibody titers was 4.47, whereas that for subjects with high antibody titers was 8.31 (P = .032). Mumps vaccine-induced cell-mediated immunity appears to be more persistent than the antibody response.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research