Randomized Study of Early versus Late Immunization with Pneumococcal Conjugate Vaccine after Allogeneic Stem Cell Transplantation | Zendy

Catherine Cordonnier | Zendy; Myriam Labopin | Zendy; Virginie Chesnel | Zendy; Patricia Ribaud | Zendy; Rafael de la Cámara | Zendy; Rodrigo Martino | Zendy; Andrew J. Ullmann | Zendy; T Parkkali | Zendy; Anna Locasciulli | Zendy; Karima Yakouben | Zendy; Karlis Pauksens | Zendy; Hermann Einsele | Zendy; Dietger Niederwieser | Zendy; Jane F. Apperley | Zendy; Per Ljungman | Zendy

Open Access

Randomized Study of Early versus Late Immunization with Pneumococcal Conjugate Vaccine after Allogeneic Stem Cell Transplantation

Author(s) -

Catherine Cordonnier,

Myriam Labopin,

Virginie Chesnel,

Patricia Ribaud,

Rafael de la Cámara,

Rodrigo Martino,

Andrew J. Ullmann,

T Parkkali,

Anna Locasciulli,

Karima Yakouben,

Karlis Pauksens,

Hermann Einsele,

Dietger Niederwieser,

Jane F. Apperley,

Per Ljungman

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/598324

Subject(s) - medicine , transplantation , pneumococcal conjugate vaccine , vaccination , pneumococcal polysaccharide vaccine , randomized controlled trial , surgery , streptococcus pneumoniae , immunology , pneumococcal disease , antibiotics , microbiology and biotechnology , biology

Invasive pneumococcal disease is a life-threatening complication after allogeneic stem cell transplantation, and at least 20% of cases occur within 1 year after transplantation. The 23-valent pneumococcal polysaccharide vaccine (PPV23) has limited efficacy, especially during the first year after transplantation. The immune response to the conjugated vaccines is expected to be better than that to the polysaccharide vaccine, but the optimal timing of vaccination is not defined. Our objective was to show that a 7-valent pneumococcal conjugate vaccine (PCV7; Prevnar) was not inferior when first given 3 months after transplantation, compared with when first given 9 months after transplantation.

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