Decreased Viral Load and Symptoms of Polyomavirus‐Associated Chronic Interstitial Cystitis after Intravesical Cidofovir Treatment | Zendy

Damon P. Eisen | Zendy; Ian R. Fraser | Zendy; Linda Sung | Zendy; Moira Finlay | Zendy; Scott Bowden | Zendy; Helen E. O’Connell | Zendy

Open Access

Decreased Viral Load and Symptoms of Polyomavirus‐Associated Chronic Interstitial Cystitis after Intravesical Cidofovir Treatment

Author(s) -

Damon P. Eisen,

Ian R. Fraser,

Linda Sung,

Moira Finlay,

Scott Bowden,

Helen E. O’Connell

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/597827

Subject(s) - cidofovir , interstitial cystitis , medicine , bk virus , hemorrhagic cystitis , polyomavirus infections , urology , urinary system , urinary bladder , bladder pain syndrome , gastroenterology , virus , chemotherapy , immunology , kidney , kidney transplantation , cyclophosphamide

Interstitial cystitis causes disabling bladder pain and is usually diagnosed in the absence of infection. We describe a patient with interstitial cystitis who had high urinary levels of polyomavirus that decreased dramatically after initiation of intravesical cidofovir treatment; the patient also showed substantial improvement in symptoms. Another patient had milder symptoms of cystitis and intermittent polyomavirus shedding. Polyomaviruses, particularly BK virus, may cause some cases of interstitial cystitis.

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