Rickettsia rickettsiiInfection Protects Human Microvascular Endothelial Cells against Staurosporine‐Induced Apoptosis by a cIAP2‐Independent Mechanism | Zendy

Jeremy Bechelli | Zendy; Elena Rydkina | Zendy; Punsiri M. Colonne | Zendy; Sangita Sahni | Zendy

Open Access

Rickettsia rickettsiiInfection Protects Human Microvascular Endothelial Cells against Staurosporine‐Induced Apoptosis by a cIAP₂‐Independent Mechanism

Author(s) -

Jeremy Bechelli,

Elena Rydkina,

Punsiri M. Colonne,

Sangita Sahni

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/597805

Subject(s) - staurosporine , biology , apoptosis , microbiology and biotechnology , inhibitor of apoptosis , programmed cell death , signal transduction , protein kinase c , genetics

Manipulation of host cell death is an important determinant of the outcome of an infection. Here, we investigate whether Rickettsia rickettsii-infected host endothelial cells resist the effects of staurosporine, a potent inducer of apoptosis, and we explore the mechanisms underlying the anti-apoptotic effect of infection.

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