Changes in Body Composition with Ritonavir‐Boosted and Unboosted Atazanavir Treatment in Combination with Lamivudine and Stavudine: A 96‐Week Randomized, Controlled Study
Author(s) -
Grace A. McComsey,
Anna Rightmire,
Victoria Wirtz,
Rong Yang,
Marina Mathew,
Donnie McGrath
Publication year - 2009
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1086/597776
Subject(s) - atazanavir , ritonavir , stavudine , medicine , lamivudine , lipoatrophy , lopinavir/ritonavir , pharmacology , gastroenterology , virology , human immunodeficiency virus (hiv) , viral load , virus , antiretroviral therapy , hepatitis b virus
This 96-week, open-label, randomized study assessed changes in body composition in treatment-naive patients infected with human immunodeficiency virus type 1 who were treated with either atazanavir or ritonavir-boosted atazanavir, in combination with stavudine and lamivudine. Both treatment groups had similar increases in trunk fat, but patients treated with ritonavir-boosted atazanavir had a significantly lower incidence of lipoatrophy.
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