Azole‐Resistant Central Nervous System Aspergillosis | Zendy

Jan W. M. van der Linden | Zendy; Rogier R. Jansen | Zendy; Dorine Bresters | Zendy; Caroline E. Visser | Zendy; Suzanne E. Geerlings | Zendy; Ed J. Kuijper | Zendy; Willem J. G. Melchers | Zendy; Paul E. Verweij | Zendy

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Azole‐Resistant Central Nervous System Aspergillosis

Author(s) -

Jan W. M. van der Linden,

Rogier R. Jansen,

Dorine Bresters,

Caroline E. Visser,

Suzanne E. Geerlings,

Ed J. Kuijper,

Willem J. G. Melchers,

Paul E. Verweij

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/597465

Subject(s) - aspergillosis , aspergillus fumigatus , medicine , azole , central nervous system , aspergillus , mycosis , antifungal , tandem repeat , microbiology and biotechnology , immunology , biology , genome , dermatology , gene , genetics

Three patients with central nervous system aspergillosis due to azole-resistant Aspergillus fumigatus (associated with a leucine substitution for histidine at codon 98 [L98H] and a 34-base pair repeat in tandem in the promoter region) are described. The patients were treated with combination therapy or with polyenes, but all patients died. Azole resistance significantly complicates the management of aspergillosis by delaying the initiation of adequate therapy and because effective alternative antifungal drugs are lacking.

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