A 28‐aa Pneumococcal Surface Adhesin A–Derived Peptide, P4, Augments Passive Immunotherapy and Rescues Mice from Fatal Pneumococcal Infection | Zendy

Gowrisankar Rajam | Zendy; Julie M. Skinner | Zendy; Nikkol Melnick | Zendy; Joseph Martinez | Zendy; George M. Carlone | Zendy; Jacquelyn S. Sampson | Zendy; Edwin W. Ades | Zendy

Open Access

A 28‐aa Pneumococcal Surface Adhesin A–Derived Peptide, P4, Augments Passive Immunotherapy and Rescues Mice from Fatal Pneumococcal Infection

Author(s) -

Gowrisankar Rajam,

Julie M. Skinner,

Nikkol Melnick,

Joseph Martinez,

George M. Carlone,

Jacquelyn S. Sampson,

Edwin W. Ades

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/597425

Subject(s) - microbiology and biotechnology , streptococcus pneumoniae , pneumococcal infections , antibody , biology , in vitro , bacterial adhesin , pathogen , antiserum , serotype , in vivo , effector , immunology , virulence , virology , antibiotics , biochemistry , gene

P4, a 28-aa peptide derived from pneumococcal surface adhesin A, is a multilineage cell activator in vitro. We hypothesized that P4-mediated activation of phagocytic cells could rapidly and substantially increase opsonophagocytosis of bacteria, which could be translated in vivo to reduced mouse morbidity from fatal pneumococcal infection.

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