Role ofHelicobacter pyloriCagA Molecular Variations in Induction of Host Phenotypes with Carcinogenic Potential | Zendy

Natasha J. Schneider | Zendy; Uma Krishna | Zendy; Judith RomeroGallo | Zendy; Dawn A. Israel | Zendy; M. Blanca Piazuelo | Zendy; M. Constanza Camargo | Zendy; Liviu A. Sicinschi | Zendy; Barbara Schneider | Zendy; Pelayo Correa | Zendy; Richard M. Peek | Zendy

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Role ofHelicobacter pyloriCagA Molecular Variations in Induction of Host Phenotypes with Carcinogenic Potential

Author(s) -

Natasha J. Schneider,

Uma Krishna,

Judith RomeroGallo,

Dawn A. Israel,

M. Blanca Piazuelo,

M. Constanza Camargo,

Liviu A. Sicinschi,

Barbara Schneider,

Pelayo Correa,

Richard M. Peek

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/597416

Subject(s) - caga , helicobacter pylori , phenotype , carcinogen , biology , host (biology) , microbiology and biotechnology , genetics , immunology , gene , virulence

Helicobacter pylori cagA-positive strains exert population-specific risks for gastric cancer. We determined whether variations in CagA phosphorylation motifs were associated with carcinogenic or proinflammatory epithelial phenotypes induced by strains from regions with divergent cancer risks (Colombia and Nashville, TN). Motif number was significantly related to levels of CagA phosphorylation and cytoskeletal abnormalities. Precancerous isolates possessed a higher number of motifs, and precancerous strains from Nashville induced higher levels of IL-8 than Colombian strains. These results indicate that CagA variants are linked with premalignant lesions in distinct populations and that epithelial responses to these strains are selective based upon locale.

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