Quantitative and Qualitative Anamnestic Immune Responses to Pneumococcal Conjugate Vaccine in HIV‐Infected and HIV‐Uninfected Children 5 Years after Vaccination | Zendy

Shabir A. Madhi | Zendy; Keith P. Klugman | Zendy; Locadiah Kuwanda | Zendy; Clare Cutland | Zendy; Helena Käyhty | Zendy; Peter V. Adrian | Zendy

Open Access

Quantitative and Qualitative Anamnestic Immune Responses to Pneumococcal Conjugate Vaccine in HIV‐Infected and HIV‐Uninfected Children 5 Years after Vaccination

Author(s) -

Shabir A. Madhi,

Keith P. Klugman,

Locadiah Kuwanda,

Clare Cutland,

Helena Käyhty,

Peter V. Adrian

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/597388

Subject(s) - vaccination , medicine , pneumococcal conjugate vaccine , human immunodeficiency virus (hiv) , immunology , virology , immune system , pneumococcal infections , conjugate vaccine , immunization , streptococcus pneumoniae , biology , microbiology and biotechnology , antibiotics

Administration of pneumococcal conjugate vaccine (PCV) to HIV-infected children during infancy confers limited long-term protection in the absence of antiretroviral therapy. The objective of the present study was to determine the immune responses to PCV at 5 years of age in HIV-infected and HIV-uninfected children who had been primed with vaccine during infancy (i.e., previous vaccinees) and in those receiving their first dose of vaccine (i.e., control subjects).

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