HIV‐1 Infection in Infants Severely Impairs the Immune Response Induced by Bacille Calmette‐Guérin Vaccine | Zendy

Nazma Mansoor | Zendy; Thomas J. Scriba | Zendy; Marwou de Kock | Zendy; Michèle Tameris | Zendy; Bernd Abel | Zendy; Alana Keyser | Zendy; Francesca Little | Zendy; Andreia Soares | Zendy; Sebastian Gelderbloem | Zendy; Silvia Mlenjeni | Zendy; Lea Denation | Zendy; Anthony Hawkridge | Zendy; W. Henry Boom | Zendy; Gilla Kaplan | Zendy; Gregory Hussey | Zendy; Willem A. Hanekom | Zendy

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HIV‐1 Infection in Infants Severely Impairs the Immune Response Induced by Bacille Calmette‐Guérin Vaccine

Author(s) -

Nazma Mansoor,

Thomas J. Scriba,

Marwou de Kock,

Michèle Tameris,

Bernd Abel,

Alana Keyser,

Francesca Little,

Andreia Soares,

Sebastian Gelderbloem,

Silvia Mlenjeni,

Lea Denation,

Anthony Hawkridge,

W. Henry Boom,

Gilla Kaplan,

Gregory Hussey,

Willem A. Hanekom

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/597304

Subject(s) - immunogenicity , medicine , vaccination , tuberculosis , immunology , immune system , bcg vaccine , virology , human immunodeficiency virus (hiv) , disease , pathology

Worldwide, most infants born to mothers infected with human immunodeficiency virus (HIV) receive bacille Calmette-Guérin (BCG) vaccine. Tuberculosis is a major cause of death among infants infected with HIV in sub-Saharan Africa, and it should be prevented. However, BCG may itself cause disease (known as "BCGosis") in these infants. Information regarding the immunogenicity of BCG is imperative for the risk/benefit assessment of BCG vaccination in HIV-infected infants; however, no such data exist.

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