Evaluation ofPlasmodium vivaxGenotyping Markers for Molecular Monitoring in Clinical Trials | Zendy

Cristian Koepfli | Zendy; Ivo Müeller | Zendy; Jutta Marfurt | Zendy; Mary Goroti | Zendy; Albert Sie | Zendy; Olive Oa | Zendy; Blaise Genton | Zendy; HansPeter Beck | Zendy; Ingrid Felger | Zendy

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Evaluation ofPlasmodium vivaxGenotyping Markers for Molecular Monitoring in Clinical Trials

Author(s) -

Cristian Koepfli,

Ivo Müeller,

Jutta Marfurt,

Mary Goroti,

Albert Sie,

Olive Oa,

Blaise Genton,

HansPeter Beck,

Ingrid Felger

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/597303

Subject(s) - genotyping , biology , microsatellite , plasmodium vivax , genetic marker , polymerase chain reaction , haplotype , typing , genetics , genotype , allele , virology , plasmodium falciparum , gene , malaria , immunology

Many antimalarial interventions are accompanied by molecular monitoring of parasite infections, and a number of molecular typing techniques based on different polymorphic marker genes are used. Here, we describe a genotyping technique that provides a fast and precise approach to study Plasmodium vivax infection dynamics during circumstances in which individual clones must be followed over time. The method was tested with samples from an in vivo drug efficacy study.

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