Detection of JC Virus DNA and Proteins in the Bone Marrow of HIV‐Positive and HIV‐Negative Patients: Implications for Viral Latency and Neurotropic Transformation | Zendy

Chen Tan | Zendy; Bruce J. Dezube | Zendy; Parul Bhargava | Zendy; Patrick Autissier | Zendy; Christian Wüthrich | Zendy; Janice S. Miller | Zendy; Igor J. Koralnik | Zendy

Open Access

Detection of JC Virus DNA and Proteins in the Bone Marrow of HIV‐Positive and HIV‐Negative Patients: Implications for Viral Latency and Neurotropic Transformation

Author(s) -

Chen Tan,

Bruce J. Dezube,

Parul Bhargava,

Patrick Autissier,

Christian Wüthrich,

Janice S. Miller,

Igor J. Koralnik

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/597117

Subject(s) - virology , human immunodeficiency virus (hiv) , latency (audio) , transformation (genetics) , bone marrow , virus , biology , dna , medicine , immunology , genetics , gene , computer science , telecommunications

We sought to determine the prevalence of JC virus (JCV) in bone marrow samples from human immunodeficiency virus (HIV)-positive and HIV-negative patients and to determine whether bone marrow is a site of latency and neurotropic transformation of JCV, the agent of progressive multifocal leukoencephalopathy (PML).

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