Functional Haplotypes That Produce Normal Ficolin‐2 Levels Protect against Clinical Leprosy | Zendy

Iara Messias-Reason | Zendy; Peter G. Kremsner | Zendy; Jürgen F. J. Kun | Zendy

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Functional Haplotypes That Produce Normal Ficolin‐2 Levels Protect against Clinical Leprosy

Author(s) -

Iara Messias-Reason,

Peter G. Kremsner,

Jürgen F. J. Kun

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/597070

Subject(s) - leprosy , haplotype , immunology , biology , mycobacterium leprae , ficolin , case control study , gene , genetics , genotype , medicine , mannan binding lectin

Host factors have been shown to play a significant role in the susceptibility to and clinical outcome of leprosy. Here, we analyze polymorphisms of the gene encoding ficolin-2 (FCN2), which is a soluble pattern-recognition molecule. A total of 158 patients with leprosy and 210 healthy control subjects from Brazil were investigated. Polymorphisms in the promoter and exon 8 of FCN2 were assessed by DNA sequencing. The distribution of functional FCN2 haplotypes amongpatients was significant different from that among the control subjects (P = .004). These results unveil an immunogenetic role for ficolin-2 in the host response against M. leprae.

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