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fallacy. Am J Epidemiol 1988; 127:893–904. 3. Greenland S, Robins J. Invited commentary: ecologic studies–biases, misconceptions, and counterexamples. Am J Epidemiol 1994; 139: 747–60. 4. Blaser MJ, Chen Y, Reibman J. Does Helicobacter pylori protect against asthma and allergy? Gut 2008; 57:561–7. 5. Höök-Nikanne J, Pérez-Pérez GI, Blaser MJ. Antigenic characterization of Helicobacter pylori strains from different parts of the world. Clin Diagn Lab Immunol 1997; 4:592–7. 6. Groves FD, Zhang L, Li J-Y, et al. Comparison of two enzyme-linked immunosorbent assay tests for diagnosis of Helicobacter pylori infection in China. Cancer Epidemiol Biomarkers Prev 1997; 6:551–2. 7. Uyub AM, Raj SM, Visvanathan R, et al. Helicobacter pylori infection in north-eastern peninsular Malaysia. Evidence for an unusually low prevalence. Scand J Gastroenterol 1994; 29:209 –13. 8. Go MF. Natural history and epidemiology of Helicobacter pylori infection. Alim Pharmacol Ther 2002; 16(Suppl 1): 3–15. 9. Linz B, Balloux F, Moodley Y, et al. An African origin for the intimate association between humans and Helicobacter pylori. Nature 2007; 445:915– 8. 10. Blaser MJ, Kirschner D. The equilibria that permit bacterial persistence in human hosts. Nature 2007; 449:843– 849. 11. Banatvala N, Mayo K, Megraud F, Jennings R, Deeks JJ, Feldman RA. The cohort effect and Helicobacter pylori. J Infect Dis 1993; 168:219–21.

Valacyclovir to Reduce Transmission of Genital Herpes Simplex Virus Infection