Delayed Microbial Cure of Lymphogranuloma Venereum Proctitis with Doxycycline Treatment | Zendy

Henry J.C. de Vries | Zendy; Vitaly Smelov | Zendy; Judith G. Middelburg | Zendy; Jolein Pleijster | Zendy; Arjen Speksnijder | Zendy; Servass A. Morré | Zendy

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Delayed Microbial Cure of Lymphogranuloma Venereum Proctitis with Doxycycline Treatment

Author(s) -

Henry J.C. de Vries,

Vitaly Smelov,

Judith G. Middelburg,

Jolein Pleijster,

Arjen Speksnijder,

Servass A. Morré

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/597011

Subject(s) - lymphogranuloma venereum , proctitis , doxycycline , medicine , chlamydia trachomatis , chlamydia , regimen , radiation proctitis , antibiotics , gastroenterology , virology , immunology , microbiology and biotechnology , disease , biology , ulcerative colitis

Microbial cure of chlamydia proctitis (lymphogranuloma venereum [LGV] and non-LGV) with doxycycline treatment was evaluated by chlamydia DNA and RNA persistence in anal swab specimens. In LGV proctitis, RNA persisted for up to 16 days. In non-LGV chlamydia proctitis, DNA was undetectable after 7 days. These findings support the Centers for Disease Control and Prevention's treatment recommendation of a 21-day doxycycline regimen for LGV proctitis and a 7-day regimen for non-LGV chlamydia proctitis. Delayed microbial cure of LGV proctitis should be considered in improved treatment regimens.

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