Hepatitis C Virus Infection of T Cells Inhibits Proliferation and Enhances Fas-Mediated Apoptosis by Down-Regulating the Expression of CD44 Splicing Variant 6 | Zendy

Yasuteru Kondo | Zendy; Keigo Machida | Zendy; Helene Minyi Liu | Zendy; Yoshiyuki Ueno | Zendy; Koju Kobayashi | Zendy; Takaji Wakita | Zendy; Tooru Shimosegawa | Zendy; Michael M. C. Lai | Zendy

Open Access

Hepatitis C Virus Infection of T Cells Inhibits Proliferation and Enhances Fas-Mediated Apoptosis by Down-Regulating the Expression of CD44 Splicing Variant 6

Author(s) -

Yasuteru Kondo,

Keigo Machida,

Helene Minyi Liu,

Yoshiyuki Ueno,

Koju Kobayashi,

Takaji Wakita,

Tooru Shimosegawa,

Michael M. C. Lai

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/596739

Subject(s) - apoptosis , biology , hepatitis c virus , microbiology and biotechnology , ns5a , jurkat cells , cd44 , t cell , virology , virus , immune system , cell , immunology , hepacivirus , biochemistry

A lymphotropic hepatitis C virus strain (HCV, SB strain, hereafter "SB-HCV") has been shown to infect established T cell lines (Molt-4 and Jurkat) and primary human naive CD4(+) T cells. During T cell development and activation, transient expression of CD44 splicing variant 6 (CD44v6) plays a significant role.

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