Gnotobiotic Piglet Infection Model for Evaluating the Safe Use of Antibiotics againstEscherichia coliO157:H7 Infection | Zendy

Quanshun Zhang | Zendy; Arthur DonohueRolfe | Zendy; Greice KrautzPeterson | Zendy; Milica Ševo | Zendy; N. Parry | Zendy; Claudia Abeijón | Zendy; Saul Tzipori | Zendy

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Gnotobiotic Piglet Infection Model for Evaluating the Safe Use of Antibiotics againstEscherichia coliO157:H7 Infection

Author(s) -

Quanshun Zhang,

Arthur DonohueRolfe,

Greice KrautzPeterson,

Milica Ševo,

N. Parry,

Claudia Abeijón,

Saul Tzipori

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/596509

Subject(s) - ciprofloxacin , antibiotics , azithromycin , shiga toxin , microbiology and biotechnology , diarrhea , biology , toxin , bloody diarrhea , medicine , escherichia coli , biochemistry , gene

Shiga toxin (Stx)-producing Escherichia coli (STEC), especially O157:H7, cause bloody diarrhea, and in 3%-15% of individuals the infection leads to hemolytic uremic syndrome (HUS) or other complications. Use of antibiotics to treat STEC infections is controversial. Here, we describe the use of piglets to evaluate the efficacy and mechanism of action of antibiotics in these infections.

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