In Leishmaniasis Due toLeishmania guyanensisInfection, Distinct Intralesional Interleukin‐10 and Foxp3 mRNA Expression Are Associated with Unresponsiveness to Treatment | Zendy

Eliane Bourreau | Zendy; Catherine Ronet | Zendy; Edith Darsissac | Zendy; M.L.Z. Lise | Zendy; D. Sainte Marie | Zendy; Emmanuel Clity | Zendy; Fabienne TacchiniCottier | Zendy; Pierre Couppié | Zendy; Pascal Launois | Zendy

Open Access

In Leishmaniasis Due toLeishmania guyanensisInfection, Distinct Intralesional Interleukin‐10 and Foxp3 mRNA Expression Are Associated with Unresponsiveness to Treatment

Author(s) -

Eliane Bourreau,

Catherine Ronet,

Edith Darsissac,

M.L.Z. Lise,

D. Sainte Marie,

Emmanuel Clity,

Fabienne TacchiniCottier,

Pierre Couppié,

Pascal Launois

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/596508

Subject(s) - immunology , leishmaniasis , leishmania , foxp3 , interleukin , messenger rna , cutaneous leishmaniasis , biology , virology , medicine , immune system , cytokine , parasite hosting , gene , genetics , world wide web , computer science

The presence of intralesional natural regulatory T cells, characterized by the expression of Foxp3 mRNA, was analyzed in patients with localized leishmaniasis due to Leishmania guyanensis infection that was unresponsive to treatment with pentamidine isethionate. Foxp3 mRNA levels were associated with unresponsiveness to treatment among patients with a lesion duration of 1 month, but this association was not observed among patients with a lesion duration of <1 month. In conclusion, high intralesional expression of Foxp3 might be an indicator of poor response to treatment, depending on the duration of lesions.

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