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The presence of intralesional natural regulatory T cells, characterized by the expression of Foxp3 mRNA, was analyzed in patients with localized leishmaniasis due to Leishmania guyanensis infection that was unresponsive to treatment with pentamidine isethionate. Foxp3 mRNA levels were associated with unresponsiveness to treatment among patients with a lesion duration of 1 month, but this association was not observed among patients with a lesion duration of &lt;1 month. In conclusion, high intralesional expression of Foxp3 might be an indicator of poor response to treatment, depending on the duration of lesions.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

In Leishmaniasis Due to<i>Leishmania guyanensis</i>Infection, Distinct Intralesional Interleukin‐10 and Foxp3 mRNA Expression Are Associated with Unresponsiveness to Treatment

In Leishmaniasis Due toLeishmania guyanensisInfection, Distinct Intralesional Interleukin‐10 and Foxp3 mRNA Expression Are Associated with Unresponsiveness to Treatment