Open AccessFunctional IL‐10 Gene Polymorphism Is Associated with Chagas Disease Cardiomyopathy
Author(s) -
Germano Carneiro Costa,
Manoel Otávio da Costa Rocha,
Paula Rocha Moreira,
Cristiane Alves Silva Menezes,
Micena Roberta Miranda Alves e Silva,
Kenneth J. Gollob,
Walderez O. Dutra
Publication year - 2008
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/596061
Subject(s) - cardiomyopathy , chagas disease , trypanosoma cruzi , allele , biology , polymorphism (computer science) , ejection fraction , cardiac function curve , gene expression , gene , immunology , medicine , genetics , heart failure , parasite hosting , world wide web , computer science
This study was designed to determine whether the functional IL-10 gene polymorphism -1082G/A is associated with the development of cardiomyopathy in individuals infected with Trypanosoma cruzi and whether interleukin (IL)-10 expression can be correlated with patients' cardiac function. Our results demonstrated that the polymorphic allele, which correlates with lower expression of IL-10, was associated with the development of Chagas disease cardiomyopathy. Accordingly, correlative analysis showed that low IL-10 expression was associated with worse cardiac function, as determined by left-ventricular ejection fraction values. Therefore, the IL-10 gene polymorphism and IL-10 expression are important in determining susceptibility to chagasic cardiomyopathy.
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