CD3ζ Down‐Modulation May Explain Vγ9Vδ2 T Lymphocyte Anergy in HIV‐Infected Patients | Zendy

Alessandra Sacchi | Zendy; Massimo Tempestilli | Zendy; Federica Turchi | Zendy; Chiara Agrati | Zendy; Rita Casetti | Zendy; Eleonora Cimini | Zendy; Cristiana Gioia | Zendy; Federico Martini | Zendy

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CD3ζ Down‐Modulation May Explain Vγ9Vδ2 T Lymphocyte Anergy in HIV‐Infected Patients

Author(s) -

Alessandra Sacchi,

Massimo Tempestilli,

Federica Turchi,

Chiara Agrati,

Rita Casetti,

Eleonora Cimini,

Cristiana Gioia,

Federico Martini

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/596047

Subject(s) - cd3 , immunology , virology , t lymphocyte , biology , t cell , lymphocyte , antigen , immune system , cd8

The aim of the present study was to explain the observed anergy of Vgamma9Vdelta2 T cells from human immunodeficiency virus (HIV)-positive patients. CD3zeta expression and interferon (IFN)-gamma production by Vgamma9Vdelta2 T cells from HIV-positive and HIV-negative subjects were analyzed. We demonstrated that Vgamma9Vdelta2 T cells from HIV-infected patients expressed a lower level of CD3zeta than did Vgamma9Vdelta2 T cells from healthy donors. A direct correlation was found between CD3zeta expression and IFN-gamma production capability by Vgamma9Vdelta2 T cells. However, activation of protein kinase C by phorbol myristate acetate is able to restore CD3zeta expression and IFN-gamma production. Our findings may contribute to clarification of the molecular mechanisms of Vgamma9Vdelta2 T cell anergy found in HIV-positive patients.

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