Recombinant Modified Vaccinia Virus Ankara Expressing the Hemagglutinin Gene Confers Protection against Homologous and Heterologous H5N1 Influenza Virus Infections in Macaques | Zendy

Joost H. C. M. Kreijtz | Zendy; Yasemin Suezer | Zendy; Gerrie de Mutsert | Zendy; Judith M. A. van den Brand | Zendy; Geert van Amerongen | Zendy; Barbara S. Schnierle | Zendy; Thijs Kuiken | Zendy; Ron A. M. Fouchier | Zendy; Johannes Löwer | Zendy; Albert D. M. E. Osterhaus | Zendy; Gerd Sutter | Zendy; Guus F. Rimmelzwaan | Zendy

Open Access

Recombinant Modified Vaccinia Virus Ankara Expressing the Hemagglutinin Gene Confers Protection against Homologous and Heterologous H5N1 Influenza Virus Infections in Macaques

Author(s) -

Joost H. C. M. Kreijtz,

Yasemin Suezer,

Gerrie de Mutsert,

Judith M. A. van den Brand,

Geert van Amerongen,

Barbara S. Schnierle,

Thijs Kuiken,

Ron A. M. Fouchier,

Johannes Löwer,

Albert D. M. E. Osterhaus,

Gerd Sutter,

Guus F. Rimmelzwaan

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/595984

Subject(s) - virology , influenza a virus subtype h5n1 , biology , hemagglutinin (influenza) , virus , heterologous , h5n1 genetic structure , immunity , influenza a virus , vaccinia , microbiology and biotechnology , immune system , recombinant dna , gene , immunology , medicine , infectious disease (medical specialty) , genetics , disease , covid-19 , pathology

Highly pathogenic avian influenza viruses of the H5N1 subtype have been responsible for an increasing number of infections in humans since 2003. More than 60% of infected individuals die, and new infections are reported frequently. In light of the pandemic threat caused by these events, the rapid availability of safe and effective vaccines is desirable. Modified vaccinia virus Ankara (MVA) expressing the hemagglutinin (HA) gene of H5N1 viruses is a promising candidate vaccine that induced protective immunity against infection with homologous and heterologous H5N1 influenza virus in mice.

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