Minority Quasispecies of Drug‐Resistant HIV‐1 That Lead to Early Therapy Failure in Treatment‐Naive and ‐Adherent Patients | Zendy

Karin J. Metzner | Zendy; Stefano Giulieri | Zendy; Stefanie A Knoepfel | Zendy; Pia Rauch | Zendy; Philippe Bürgisser | Zendy; Sabine Yerly | Zendy; Huldrych F. Günthard | Zendy; Matthias Cavassini | Zendy

Open Access

Minority Quasispecies of Drug‐Resistant HIV‐1 That Lead to Early Therapy Failure in Treatment‐Naive and ‐Adherent Patients

Author(s) -

Karin J. Metzner,

Stefano Giulieri,

Stefanie A Knoepfel,

Pia Rauch,

Philippe Bürgisser,

Sabine Yerly,

Huldrych F. Günthard,

Matthias Cavassini

Publication year - 2008

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/595703

Subject(s) - viral quasispecies , medicine , resistance mutation , virology , reverse transcriptase , efavirenz , population , nevirapine , drug resistance , lamivudine , zidovudine , reverse transcriptase inhibitor , viral load , virus , viral disease , polymerase chain reaction , biology , antiretroviral therapy , hepatitis b virus , hepatitis c virus , microbiology and biotechnology , genetics , environmental health , gene

Early virological failure of antiretroviral therapy associated with the selection of drug-resistant human immunodeficiency virus type 1 in treatment-naive patients is very critical, because virological failure significantly increases the risk of subsequent failures. Therefore, we evaluated the possible role of minority quasispecies of drug-resistant human immunodeficiency virus type 1, which are undetectable at baseline by population sequencing, with regard to early virological failure.

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