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Toll-like receptor (TLR) 2 is the principal recognition receptor for gram-positive microbes. However, in some gram-positive bacterial infections, TLR2 is dispensable. One of the outstanding questions regarding host-bacteria interactions is why TLR2 is essential in some infections but dispensable in others.

Signals Triggered by a Bacterial Pore-Forming Toxin Contribute to Toll-Like Receptor Redundancy in Gram-Positive Bacterial Recognition