Signals Triggered by a Bacterial Pore-Forming Toxin Contribute to Toll-Like Receptor Redundancy in Gram-Positive Bacterial Recognition | Zendy

Nelson O. Gekara | Zendy; Nicole Dietrich | Zendy; Marcin Łyszkiewicz | Zendy; Stefan Lienenklaus | Zendy; Siegfried Weiß | Zendy

Open Access

Signals Triggered by a Bacterial Pore-Forming Toxin Contribute to Toll-Like Receptor Redundancy in Gram-Positive Bacterial Recognition

Author(s) -

Nelson O. Gekara,

Nicole Dietrich,

Marcin Łyszkiewicz,

Stefan Lienenklaus,

Siegfried Weiß

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/595562

Subject(s) - microbiology and biotechnology , toll like receptor , toxin , microbial toxins , gram , receptor , redundancy (engineering) , bacteria , toll , gram negative bacteria , biology , chemistry , immunology , innate immune system , computer science , escherichia coli , biochemistry , gene , genetics , operating system

Toll-like receptor (TLR) 2 is the principal recognition receptor for gram-positive microbes. However, in some gram-positive bacterial infections, TLR2 is dispensable. One of the outstanding questions regarding host-bacteria interactions is why TLR2 is essential in some infections but dispensable in others.

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