Long-Lasting Antibodies Detected by atrans-Sialidase Inhibition Assay of Sera from Parasite-Free, Serologically Cured Chagasic Patients | Zendy

María Susana Leguizamón | Zendy; Graciela Russomando | Zendy; Alejandro O. Luquetti | Zendy; Anis Rassi | Zendy; María Almirón | Zendy; Stella Maris González-Cappa | Zendy; Alberto C.C. Frasch | Zendy; Oscar Campetella | Zendy

Open Access

Long-Lasting Antibodies Detected by atrans-Sialidase Inhibition Assay of Sera from Parasite-Free, Serologically Cured Chagasic Patients

Author(s) -

María Susana Leguizamón,

Graciela Russomando,

Alejandro O. Luquetti,

Anis Rassi,

María Almirón,

Stella Maris González-Cappa,

Alberto C.C. Frasch,

Oscar Campetella

Publication year - 1997

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/593697

Subject(s) - trypanosoma cruzi , benznidazole , chagas disease , antibody , virology , parasite hosting , biology , microbiology and biotechnology , trypanosomiasis , immunology , xenodiagnosis , world wide web , computer science

A test based on the inhibition by antibodies of the trans-sialidase was used to analyze infection by Trypanosoma cruzi, the agent of Chagas' disease. Sera collected during the longitudinal follow-up of benznidazole-treated acutely and congenitally infected patients became negative for T. cruzi as determined by tests presently used to assess cure; however, the sera remained positive for T. cruzi by the trans-sialidase inhibition assay (TIA) up to 14 years after treatment. Therefore, TIA is a highly sensitive marker for previous T. cruzi infection.

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