Open AccessA Mouse Model ofBorreliaMeningitis after Intradermal Injection
Author(s) -
Juan Carlos GarcíaMoncó,
Nancy S. Miller,
P. Bryon Backenson,
Pedro Anda,
Jorge L. Benach
Publication year - 1997
Publication title -
the journal of infectious diseases
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/593681
Subject(s) - meningitis , meningoencephalitis , borrelia , intradermal injection , inoculation , medicine , virology , immunology , microbiology and biotechnology , biology , antibody , borrelia burgdorferi , surgery
Both young and adult C3H/HeN mice developed meningitis within 3 weeks of intradermal inoculation with a newly identified uncultivable Borrelia species, an agent of human relapsing fever. Meningoencephalitis with perivascular infiltrates and plexitis developed at approximately 25 days after inoculation. Infiltrates were composed of B and plasma cells and monocytes. This model recreated the meningitis associated with spirochetal infections through an intradermal route of infection.
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