Effect of Praziquantel Treatment during Pregnancy on Cytokine Responses to Schistosome Antigens: Results of a Randomized, Placebo‐Controlled Trial | Zendy

Robert Tweyongyere | Zendy; Patrice A. Mawa | Zendy; Sophy Ngomwegi | Zendy; Juliet Ndibazza | Zendy; Trinh Duong | Zendy; Birgitte J. Vennervald | Zendy; David W. Dunne | Zendy; E. KatungukaRwakishaya | Zendy; Alison M. Elliott | Zendy

Open Access

Effect of Praziquantel Treatment during Pregnancy on Cytokine Responses to Schistosome Antigens: Results of a Randomized, Placebo‐Controlled Trial

Author(s) -

Robert Tweyongyere,

Patrice A. Mawa,

Sophy Ngomwegi,

Juliet Ndibazza,

Trinh Duong,

Birgitte J. Vennervald,

David W. Dunne,

E. KatungukaRwakishaya,

Alison M. Elliott

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/593215

Subject(s) - praziquantel , schistosomiasis , schistosoma mansoni , pregnancy , immunology , medicine , helminthiasis , schistosoma , placebo , cytokine , antigen , biology , helminths , pathology , genetics , alternative medicine

Praziquantel treatment of schistosomiasis boosts antischistosome responses, with type 2 helper T cell bias that may contribute to immunologically mediated killing and to protection against reinfection. Praziquantel treatment during pregnancy was recommended in 2002, but the immunological effects of the treatment had not been investigated.

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