Impact of the Novel Hepatotropic Viruslike Agent NV‐F during Chronic Hepatitis C Virus Infection | Zendy

ChauTing Yeh | Zendy; ChaoWei Hsu | Zendy; MingLing Chang | Zendy; MeiLing Tsao | Zendy

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Impact of the Novel Hepatotropic Viruslike Agent NV‐F during Chronic Hepatitis C Virus Infection

Author(s) -

ChauTing Yeh,

ChaoWei Hsu,

MingLing Chang,

MeiLing Tsao

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/593178

Subject(s) - coinfection , medicine , virus , virology , hepatitis c virus , chronic hepatitis , interferon , immunology

NV-F is a novel hepatotropic viruslike agent. To investigate the impact of the NV-F agent during chronic hepatitis C virus (HCV) infection, 101 consecutive patients with chronic HCV infection were evaluated. NV-F DNA in serum samples and NV-F antigen expression in liver tissues were assessed. All patients subsequently received a 6-month course of interferon-based antiviral therapy. Of the 101 patients, 30 (29.7%) were positive for serum NV-F DNA. Immunohistochemical analysis revealed positive NV-F antigen expression in the liver in 14 of these 30 patients. Patients positive for serum NV-F DNA had significantly higher serum aminotransferase levels (P < .001) and higher Knodell histology activity index values (P < .001). The sustained virological response rate for HCV clearance was not significantly different between patients with and those without detectable serum NV-F DNA. In conclusion, coinfection of the NV-F agent in chronic HCV infection is associated with more severe hepatitis activity.

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