Induction of CC and CXC Chemokines in Human Antigen‐Presenting Dendritic Cells by the Pneumococcal Proteins Pneumolysin and CbpA, and the Role Played by Toll‐Like Receptor 4, NF‐κB, and Mitogen‐Activated Protein Kinases | Zendy

Jolanta Bernatoniene | Zendy; Qibo Zhang | Zendy; Semih Doğan | Zendy; Timothy J. Mitchell | Zendy; James C. Paton | Zendy; Adam Finn | Zendy

Open Access

Induction of CC and CXC Chemokines in Human Antigen‐Presenting Dendritic Cells by the Pneumococcal Proteins Pneumolysin and CbpA, and the Role Played by Toll‐Like Receptor 4, NF‐κB, and Mitogen‐Activated Protein Kinases

Author(s) -

Jolanta Bernatoniene,

Qibo Zhang,

Semih Doğan,

Timothy J. Mitchell,

James C. Paton,

Adam Finn

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/593177

Subject(s) - chemokine , pneumolysin , biology , immunology , microbiology and biotechnology , immune system , streptococcus pneumoniae , antibiotics

Choline-binding protein A (CbpA) and pneumolysin (Ply) can induce the expression and release of chemokines by human cells, which might modulate specific immune responses. In dendritic cells (DCs), such effects could be important for the size and character of the immunity induced if administered as vaccines. We studied the induction of CCL and CXCL chemokines by CbpA and Ply in DCs and related signaling pathways.

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