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“Gently Rough”: The Vaccine Potential of aSalmonella entericaRegulatory Lipopolysaccharide Mutant
Author(s) -
Gábor Nagy,
Tamás Palkovics,
Andreas Otto,
Harald Kusch,
Béla Kocsis,
Ulrich Dobrindt,
Susanne Engelmann,
Michael Hecker,
Levente Emödy,
Tibor Pál,
Jörg Hacker
Publication year - 2008
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/593069
Subject(s) - aroa , immunogenicity , biology , microbiology and biotechnology , salmonella enterica , antigen , bacterial outer membrane , lipopolysaccharide , epitope , heterologous , mutant , lipid a , salmonella , serotype , virology , enterobacteriaceae , escherichia coli , genetics , gene , bacteria , immunology
An alternative to multivalent vaccines could be to construct strains capable of conferring broad protection through shared antigens. Down-regulation of immunodominant major antigens has been proposed to enhance the immunogenicity of conserved antigens.

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