Immunodominance and Recognition of Intracellular Pathogens | Zendy

Emma H. Wilson | Zendy; Christopher A. Hunter | Zendy

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Immunodominance and Recognition of Intracellular Pathogens

Author(s) -

Emma H. Wilson,

Christopher A. Hunter

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/593020

Subject(s) - immunodominance , intracellular , biology , microbiology and biotechnology , virology , medicine , immunology , antigen , epitope , genetics

The concept of immunodominance during infection involves the generation of a focused immune response to a few of the many possible pathogen-derived antigenic determinants. The development of technical approaches to identify these antigens and predictive algorithms for major histocompatibility complex (MHC)binding peptides have proven key in starting to dissect these events. When combined with the availability of MHC I and II tetramers to identify pathogen specific CD8+ and CD4+ T cells, these methods have provided many insights into the basic biology of an immune response. These approaches have revealed that a limited number of immunodominant

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