Open AccessParasite Stage–Specific Recognition of EndogenousToxoplasma gondii–Derived CD8+T Cell Epitopes
Author(s) -
EvaMaria Frickel,
Nivedita Sahoo,
Johnathan Hopp,
MarcJan Gubbels,
Mary Patricia J. Craver,
Laura J. Knoll,
Hidde L. Ploegh,
Gijsbert M. Grotenbreg
Publication year - 2008
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/593019
Subject(s) - toxoplasma gondii , epitope , biology , cd8 , intracellular parasite , cytotoxic t cell , t cell , major histocompatibility complex , toxoplasmosis , virology , antigen , immunology , chronic infection , immune system , microbiology and biotechnology , antibody , in vitro , genetics
BALB/c mice control infection with the obligate intracellular parasite Toxoplasma gondii and develop a latent chronic infection in the brain, as do immunocompetent humans. Interferon-gamma-producing CD8+ T cells provide essential protection against T. gondii infection, but the epitopes recognized have so far remained elusive.