Parasite Stage–Specific Recognition of EndogenousToxoplasma gondii–Derived CD8+T Cell Epitopes | Zendy

EvaMaria Frickel | Zendy; Nivedita Sahoo | Zendy; Johnathan Hopp | Zendy; MarcJan Gubbels | Zendy; Mary Patricia J. Craver | Zendy; Laura J. Knoll | Zendy; Hidde L. Ploegh | Zendy; Gijsbert M. Grotenbreg | Zendy

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Parasite Stage–Specific Recognition of EndogenousToxoplasma gondii–Derived CD8⁺T Cell Epitopes

Author(s) -

EvaMaria Frickel,

Nivedita Sahoo,

Johnathan Hopp,

MarcJan Gubbels,

Mary Patricia J. Craver,

Laura J. Knoll,

Hidde L. Ploegh,

Gijsbert M. Grotenbreg

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/593019

Subject(s) - toxoplasma gondii , epitope , biology , cd8 , intracellular parasite , cytotoxic t cell , t cell , major histocompatibility complex , toxoplasmosis , virology , antigen , immunology , chronic infection , immune system , microbiology and biotechnology , antibody , in vitro , genetics

BALB/c mice control infection with the obligate intracellular parasite Toxoplasma gondii and develop a latent chronic infection in the brain, as do immunocompetent humans. Interferon-gamma-producing CD8+ T cells provide essential protection against T. gondii infection, but the epitopes recognized have so far remained elusive.

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