Polymorphisms in the Mannan‐Binding Lectin Gene Are Not Associated with Questionnaire‐Reported Respiratory Tract Infections in Children | Zendy

Jopje M. Ruskamp | Zendy; Maarten O. Hoekstra | Zendy; Dirkje S. Postma | Zendy; Marjan Kerkhof | Zendy; R. W. B. Bottema | Zendy; Gerard H. Koppelman | Zendy; Maroeska M. Rovers | Zendy; Alet H. Wijga | Zendy; Johan C. de Jongste | Zendy; Bert Brunekreef | Zendy; Elisabeth A. M. Sanders | Zendy

Open Access

Polymorphisms in the Mannan‐Binding Lectin Gene Are Not Associated with Questionnaire‐Reported Respiratory Tract Infections in Children

Author(s) -

Jopje M. Ruskamp,

Maarten O. Hoekstra,

Dirkje S. Postma,

Marjan Kerkhof,

R. W. B. Bottema,

Gerard H. Koppelman,

Maroeska M. Rovers,

Alet H. Wijga,

Johan C. de Jongste,

Bert Brunekreef,

Elisabeth A. M. Sanders

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/592989

Subject(s) - mannan binding lectin , mannan , immunology , respiratory tract infections , respiratory tract , lectin , respiratory system , medicine , population , cohort , biology , environmental health , polysaccharide , biochemistry

Low mannan-binding lectin (MBL) levels, caused by MBL2 polymorphisms, are suggested to contribute to susceptibility to respiratory tract infections (RTIs), particularly early in life. Large-scale replication of previous associations is needed, however. We investigated the association between MBL2 polymorphisms and the frequency of RTI in a large population-based birth cohort of white children.

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