Association of Early Interferon‐γ Production with Immunity to Clinical Malaria: A Longitudinal Study among Papua New Guinean Children | Zendy

Marthe C. D’Ombrain | Zendy; Leanne J. Robinson | Zendy; Danielle I. Stanisic | Zendy; Jack Taraika | Zendy; Nicholas J. Bernard | Zendy; P Michon | Zendy; Ivo Müeller | Zendy; Louis Schofield | Zendy

Open Access

Association of Early Interferon‐γ Production with Immunity to Clinical Malaria: A Longitudinal Study among Papua New Guinean Children

Author(s) -

Marthe C. D’Ombrain,

Leanne J. Robinson,

Danielle I. Stanisic,

Jack Taraika,

Nicholas J. Bernard,

P Michon,

Ivo Müeller,

Louis Schofield

Publication year - 2008

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/592971

Subject(s) - immunology , malaria , plasmodium falciparum , interferon gamma , immunity , acquired immune system , cellular immunity , immune system , biology , malaria vaccine , peripheral blood mononuclear cell , parasitemia , innate immune system , interferon , medicine , virology , in vitro , genetics

Elucidating the cellular and molecular basis of naturally acquired immunity to Plasmodium falciparum infection would assist in developing a rationally based malaria vaccine. Innate, intermediate, and adaptive immune mechanisms are all likely to contribute to immunity. Interferon-gamma (IFN-gamma) has been implicated in both protection against and the pathogenesis of malaria in humans. In addition, considerable heterogeneity exists among rapid IFN-gamma responses to P. falciparum in malaria-naive donors. The question remains whether similar heterogeneity is observed in malaria-exposed individuals and whether high, medium, or low IFN-gamma responsiveness is differentially associated with protective immunity or morbidity.

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