Down‐Regulation of Interleukin‐7 Receptor (CD127) in HIV Infection Is Associated with T Cell Activation and Is a Main Factor Influencing Restoration of CD4+Cells after Antiretroviral Therapy | Zendy

José M. Benito | Zendy; Mariola López | Zendy; Sara Lozano | Zendy; Juan GonzálezLahoz | Zendy; Vincent Soriano | Zendy

Open Access

Down‐Regulation of Interleukin‐7 Receptor (CD127) in HIV Infection Is Associated with T Cell Activation and Is a Main Factor Influencing Restoration of CD4⁺Cells after Antiretroviral Therapy

Author(s) -

José M. Benito,

Mariola López,

Sara Lozano,

Juan GonzálezLahoz,

Vincent Soriano

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/592716

Subject(s) - interleukin 7 receptor , cd8 , viremia , cd38 , immunology , biology , t cell , virology , immune system , virus , il 2 receptor , stem cell , microbiology and biotechnology , cd34

Factors influencing the depletion of CD4(+) cells and the restoration of CD4(+) cells after antiretroviral therapy are not completely understood. Recently, attention has been paid to interleukin (IL)-7 and its receptor (CD127). We analyzed the influence of T cell activation and of suppression of viremia with antiretroviral therapy on this system, as well as its role in CD4(+) cell restoration after long-term antiretroviral therapy.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research