Plasma Folate Level and High‐Dose Folate Supplementation Predict Sulfadoxine‐Pyrimethamine Treatment Failure in Pregnant Women in Western Kenya Who Have Uncomplicated Malaria | Zendy

Anna Maria van Eijk | Zendy; Peter Ouma | Zendy; John Williamson | Zendy; Feiko O. ter Kuile | Zendy; Monica E. Parise | Zendy; Kephas Otieno | Zendy; Mary J. Hamel | Zendy; John Ayisi | Zendy; Simon Kariuki | Zendy; Piet A. Kager | Zendy; Laurence Slutsker | Zendy

Open Access

Plasma Folate Level and High‐Dose Folate Supplementation Predict Sulfadoxine‐Pyrimethamine Treatment Failure in Pregnant Women in Western Kenya Who Have Uncomplicated Malaria

Author(s) -

Anna Maria van Eijk,

Peter Ouma,

John Williamson,

Feiko O. ter Kuile,

Monica E. Parise,

Kephas Otieno,

Mary J. Hamel,

John Ayisi,

Simon Kariuki,

Piet A. Kager,

Laurence Slutsker

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/592715

Subject(s) - sulfadoxine/pyrimethamine , malaria , medicine , sulfadoxine , pyrimethamine , pregnancy , obstetrics , physiology , immunology , biology , plasmodium falciparum , genetics

Sulfadoxine-pyrimethamine (SP) inhibits folate metabolism by the malaria parasite. We investigated the association between folate levels and SP failure in pregnant women. Data from a trial to assess the effect that folate supplementation has on SP failure in 467 pregnant women were analyzed. Plasma folate levels were determined at enrollment and at day 7. High baseline folate levels, high parasite densities, and age <20 years were risk factors for SP failure. High-dose (5 mg daily) folate supplementation or high folate levels at day 7 were independent risk factors. Therefore, pregnant women receiving SP should receive low-/moderate-dose folate supplementation.

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