Therapeutic Use of Infliximab in Tuberculosis to Control Severe Paradoxical Reaction of the Brain and Lymph Nodes | Zendy

Timothy Blackmore | Zendy; Laurens Manning | Zendy; William J. Taylor | Zendy; Robert S. Wallis | Zendy

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Therapeutic Use of Infliximab in Tuberculosis to Control Severe Paradoxical Reaction of the Brain and Lymph Nodes

Author(s) -

Timothy Blackmore,

Laurens Manning,

William J. Taylor,

Robert S. Wallis

Publication year - 2008

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/592695

Subject(s) - medicine , infliximab , paradoxical reaction , tuberculosis , immune system , immunology , mycobacterium tuberculosis , tumor necrosis factor alpha , disease , central nervous system , pathology

Paradoxical reactions are immune-mediated exacerbations of disease triggered by tuberculosis treatment. Paradoxical reactions involving the central nervous system may be life threatening. Infliximab (tumor necrosis factor antibody) profoundly inhibits cellular immune responses to Mycobacterium tuberculosis. We describe a case in which infliximab was used to control steroid-resistant tuberculosis paradoxical reaction involving the central nervous system.

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