Increased Detectability of Plasma HIV‐1 RNA after Introduction of a New Assay and Altered Specimen‐Processing Procedures | Zendy

Peter F. Rebeiro | Zendy; Asghar Kheshti | Zendy; Sally Bebawy | Zendy; Samuel E. Stinnette | Zendy; Husamettin Erdem | Zendy; YiWei Tang | Zendy; Timothy R. Sterling | Zendy; Stephen Raffanti | Zendy; Richard T. D’Aquila | Zendy

Open Access

Increased Detectability of Plasma HIV‐1 RNA after Introduction of a New Assay and Altered Specimen‐Processing Procedures

Author(s) -

Peter F. Rebeiro,

Asghar Kheshti,

Sally Bebawy,

Samuel E. Stinnette,

Husamettin Erdem,

YiWei Tang,

Timothy R. Sterling,

Stephen Raffanti,

Richard T. D’Aquila

Publication year - 2008

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/592693

Subject(s) - rna , human immunodeficiency virus (hiv) , medicine , virology , human plasma , plasma , virus , fresh frozen plasma , lentivirus , viral disease , immunology , chromatography , biology , chemistry , gene , biochemistry , physics , platelet , quantum mechanics

After changes to assay and specimen-processing methods, plasma human immunodeficiency virus type 1 (HIV-1) RNA was frequently detectable in patients who previously had well-suppressed HIV-1 RNA levels. This artifact is attributable to shipping frozen plasma in primary plasma preparation tubes and is not caused by the HIV-1 RNA detection assay; it can be avoided by shipping plasma in a secondary tube.

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