Rapid Increase in the Prevalence of Sulfadoxine‐Pyrimethamine Resistance amongPlasmodium falciparumIsolated from Pregnant Women in Ghana | Zendy

Frank P. Mockenhaupt | Zendy; George BeduAddo | Zendy; Teunis A. Eggelte | Zendy; Lena Hommerich | Zendy; Ville Holmberg | Zendy; Christa von Oertzen | Zendy; Ulrich Bienzle | Zendy

Open Access

Rapid Increase in the Prevalence of Sulfadoxine‐Pyrimethamine Resistance amongPlasmodium falciparumIsolated from Pregnant Women in Ghana

Author(s) -

Frank P. Mockenhaupt,

George BeduAddo,

Teunis A. Eggelte,

Lena Hommerich,

Ville Holmberg,

Christa von Oertzen,

Ulrich Bienzle

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/592455

Subject(s) - sulfadoxine/pyrimethamine , sulfadoxine , malaria , plasmodium falciparum , pyrimethamine , pregnancy , drug resistance , medicine , obstetrics , biology , virology , microbiology and biotechnology , immunology , genetics

Use of intermittent preventive treatment with sulfadoxine-pyrimethamine (SP) during pregnancy (IPTp-SP) has become policy in much of sub-Saharan Africa but crucially depends on the efficacy of SP. We assessed the frequency of the dhfr triple mutation among Plasmodium falciparum isolates obtained from pregnant Ghanaian women in 1998, 2000, and 2006. The prevalence of the triple mutation, which confers resistance to SP, doubled from 36% to 73% during the study period (P<.001). In 2006, the prevalence was virtually identical among women of early gestation and delivering women with or without a history of IPTp-SP use, indicating that such treatment did not select for mutant parasites. Nevertheless, IPTp-SP may be outdated by drug resistance before it is fully implemented.

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