Association of a Single‐Nucleotide Polymorphism in the Pregnane X Receptor (PXR63396C→T) with Reduced Concentrations of Unboosted Atazanavir | Zendy

Marco Siccardi | Zendy; Antonio D’Avolio | Zendy; Lorena Baietto | Zendy; Sara Gibbons | Zendy; Mauro Sciandra | Zendy; Daniela Colucci | Zendy; Stefano Bonora | Zendy; Saye Khoo | Zendy; David Back | Zendy; Giovanni Di Perri | Zendy; Andrew Owen | Zendy

Open Access

Association of a Single‐Nucleotide Polymorphism in the Pregnane X Receptor (PXR63396C→T) with Reduced Concentrations of Unboosted Atazanavir

Author(s) -

Marco Siccardi,

Antonio D’Avolio,

Lorena Baietto,

Sara Gibbons,

Mauro Sciandra,

Daniela Colucci,

Stefano Bonora,

Saye Khoo,

David Back,

Giovanni Di Perri,

Andrew Owen

Publication year - 2008

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/592304

Subject(s) - medicine , atazanavir , pregnane x receptor , odds ratio , single nucleotide polymorphism , polymorphism (computer science) , genotype , cyp3a4 , pharmacology , pregnane , receptor , gastroenterology , endocrinology , genetics , immunology , metabolism , nuclear receptor , biology , antiretroviral therapy , gene , human immunodeficiency virus (hiv) , viral load , transcription factor , cytochrome p450

This study investigated pregnane X receptor polymorphisms in relation to unboosted atazanavir plasma concentrations in 2 cohorts of patients. The polymorphism 63396T-->C predicted concentrations below the minimum effective concentration (150 ng/mL) with odds ratios of 18 (P = .008) and 5.13 (P = .02). Prospective studies determining potential clinical usefulness are now warranted.

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