Polymorphic Variability in the Interleukin (IL)–1β Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL‐1β Production | Zendy

Collins Ouma | Zendy; Gregory C. Davenport | Zendy; Gordon A. Awandare | Zendy; Christopher Keller | Zendy; Tom Were | Zendy; Michael F. Otieno | Zendy; John Vulule | Zendy; Jeremy Martinson | Zendy; John Michael Ong’echa | Zendy; Robert E. Ferrell | Zendy; Douglas J. Perkins | Zendy

Open Access

Polymorphic Variability in the Interleukin (IL)–1β Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL‐1β Production

Author(s) -

Collins Ouma,

Gregory C. Davenport,

Gordon A. Awandare,

Christopher Keller,

Tom Were,

Michael F. Otieno,

John Vulule,

Jeremy Martinson,

John Michael Ong’echa,

Robert E. Ferrell,

Douglas J. Perkins

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/592055

Subject(s) - parasitemia , odds ratio , sma* , immunology , haplotype , interleukin 10 , biology , cytokine , medicine , plasmodium falciparum , malaria , gene , genetics , allele , mathematics , combinatorics

Interleukin (IL)-1beta is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1beta polymorphic variability in conditioning the immunopathogenesis of severe malarial anemia (SMA) remains undefined, relationships between IL-1beta promoter variants (-31C/T and -511A/G), SMA (hemoglobin [Hb] level <6.0 g/dL), and circulating IL-1beta levels were investigated in children with parasitemia (n= 566) from western Kenya. The IL-1beta promoter haplotype -31C/-511A (CA) was associated with increased risk of SMA (Hb level <6.0 g/dL; odds ratio [OR], 1.98 [95% confidence interval {CI}, 1.55-2.27]; P < .05) and reduced circulating IL-1beta levels (p <.05). The TA (-31T/-511A) haplotype was nonsignificantly associated with protection against SMA (OR, 0.52 [95% CI, 0.18-1.16]; p =.11) and elevated IL-1beta production ( p<.05). Compared with the non-SMA group, children with SMA had significantly lower IL-1beta levels and nonsignificant elevations in both IL-1 receptor antagonist (IL-1Ra) and the ratio of IL-1Ra to IL-1beta. The results presented demonstrate that variation in IL-1beta promoter conditions susceptibility to SMA and functional changes in circulating IL-1beta levels.

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