Solenopsin A, a Venom Alkaloid from the Fire AntSolenopsis invicta,Inhibits Quorum‐Sensing Signaling inPseudomonas aeruginosa | Zendy

Junguk Park | Zendy; Gunnar F. Kaufmann | Zendy; J. Phillip Bowen | Zendy; Jack L. Arbiser | Zendy; Kim D. Janda | Zendy

Open Access

Solenopsin A, a Venom Alkaloid from the Fire AntSolenopsis invicta,Inhibits Quorum‐Sensing Signaling inPseudomonas aeruginosa

Author(s) -

Junguk Park,

Gunnar F. Kaufmann,

J. Phillip Bowen,

Jack L. Arbiser,

Kim D. Janda

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/591916

Subject(s) - quorum sensing , pseudomonas aeruginosa , virulence , fire ant , biology , virulence factor , microbiology and biotechnology , venom , homoserine , signal transduction , gene , bacteria , biochemistry , ecology , hymenoptera , genetics

In Pseudomonas aeruginosa, quorum-sensing (QS) signaling regulates the expression of virulence factors and thus represents an attractive new target for anti-infective therapy. In the present study, we investigated whether solenopsin A, a venom alkaloid from the fire ant, possessed agonistic or antagonistic QS signaling activity in P. aeruginosa. We evaluated the modulation of virulence factor expression and transcriptional levels of QS-regulated genes in P. aeruginosa by solenopsin A and demonstrated that solenopsin A efficiently disrupted QS signaling. Interestingly, exogenously added C(4)-homoserine lactone (HSL), but not 3-oxo-C(12)-HSL, restored P. aeruginosa QS signaling, suggesting that solenopsin A targets the C(4)-HSL-dependent rhl QS system.

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