Mitochondrial DNA Haplogroups and Highly Active Antiretroviral Therapy–Related Lipodystrophy | Zendy

Milesi | Zendy; Giovanni Guaraldi | Zendy; Gabriella Orlando | Zendy; Caterina Durante | Zendy; Marcello Pinti | Zendy; Elisa Nemes | Zendy; Giulia Nardini | Zendy; Giuseppe Passarino | Zendy; Marina Cocchi | Zendy; Roberto Esposito | Zendy; Cristina Mussini | Zendy; Andrea Cossarizza | Zendy

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Mitochondrial DNA Haplogroups and Highly Active Antiretroviral Therapy–Related Lipodystrophy

Author(s) -

Milesi,

Giovanni Guaraldi,

Gabriella Orlando,

Caterina Durante,

Marcello Pinti,

Elisa Nemes,

Giulia Nardini,

Giuseppe Passarino,

Marina Cocchi,

Roberto Esposito,

Cristina Mussini,

Andrea Cossarizza

Publication year - 2008

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/591706

Subject(s) - haplogroup , lipodystrophy , human mitochondrial dna haplogroup , medicine , population , insulin resistance , mitochondrial dna , gastroenterology , haplotype , endocrinology , viral load , biology , obesity , immunology , genetics , genotype , antiretroviral therapy , human immunodeficiency virus (hiv) , environmental health , gene

The combination of different point mutations in mitochondrial DNA (mtDNA), which are defined as haplogroups, may cause modification in organelle function and may be involved in several pathologies. We analyzed the distribution of mtDNA polymorphisms in human immunodeficiency virus (HIV)-infected patients with lipodystrophy, a relevant adverse event caused by highly active antiretroviral therapy, and their correlation with metabolic and viroimmunologic parameters.

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