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Recent studies have suggested that, in addition to Toll-like receptor (TLR) 2, other pattern recognition receptors mediate activation of the immune response after infection of the central nervous system (CNS) with Streptococcus pneumoniae (SP).

Innate Immunity to Pneumococcal Infection of the Central Nervous System Depends on Toll‐Like Receptor (TLR) 2 and TLR4