Human Platelets AttenuateAspergillusSpecies via Granule‐Dependent Mechanisms | Zendy

Susanne Perkhofer | Zendy; Beate E. Kehrel | Zendy; Manfred P. Dierich | Zendy; J. Peter Donnelly | Zendy; Walter Nußbaumer | Zendy; Johann Hofmann | Zendy; Christof von Eiff | Zendy; Cornelia LassFlörl | Zendy

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Human Platelets AttenuateAspergillusSpecies via Granule‐Dependent Mechanisms

Author(s) -

Susanne Perkhofer,

Beate E. Kehrel,

Manfred P. Dierich,

J. Peter Donnelly,

Walter Nußbaumer,

Johann Hofmann,

Christof von Eiff,

Cornelia LassFlörl

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/591458

Subject(s) - platelet , granule (geology) , aspergillus , microbiology and biotechnology , chemistry , biology , immunology , paleontology

Using laser scanning microscopy, we investigated whether platelets are capable of internalizing Aspergillus conidia and examined Aspergillus-platelet adherence. The influence of platelets on fungal growth was evaluated by assessing galactomannan (GM) release, hyphal elongation, and colony size. A secretion assay with [(3)H]-serotonin (5-hydroxytryptamine [5-HT]) was performed. Exposure to platelets resulted in significantly decreased GM release (p<.05), hyphal elongation (p<.001), colony size, pigmentation, and 5-HT release ( p<.05). A lack of antifungal effects was observed with the microfilament inhibitor cytochalasin D. Platelets attenuate the virulence of Aspergillus species in vitro on the basis of granule-dependent effects.

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