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Human immunodeficiency virus (HIV) load is suppressed during dengue virus infection. The NS5A phosphoprotein of GB virus C (a related flavivirus) inhibits HIV replication in vitro. To determine whether the dengue virus NS5 protein inhibits HIV replication, CD4(+) T cell lines expressing this protein were generated. HIV replication in dengue virus NS5-expressing cells decreased by &gt;90% compared with control cells (P &lt; .01), and this was mediated in part by decreased HIV coreceptor (CXCR4) expression and increased production of SDF-1. Thus, the dengue virus NS5 protein inhibits HIV replication in vitro, potentially explaining the reduction in HIV load observed during acute dengue virus infection.

Expression of the Dengue Virus Type 2 NS5 Protein in a CD4+T Cell Line Inhibits HIV Replication

Expression of the Dengue Virus Type 2 NS5 Protein in a CD4⁺T Cell Line Inhibits HIV Replication