Expression of the Dengue Virus Type 2 NS5 Protein in a CD4+T Cell Line Inhibits HIV Replication | Zendy

James H. McLinden | Zendy; Jack T. Stapleton | Zendy; Qing Chang | Zendy; Jinhua Xiang | Zendy

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Expression of the Dengue Virus Type 2 NS5 Protein in a CD4⁺T Cell Line Inhibits HIV Replication

Author(s) -

James H. McLinden,

Jack T. Stapleton,

Qing Chang,

Jinhua Xiang

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/591254

Subject(s) - dengue virus , virology , antibody dependent enhancement , virus , dengue fever , viral replication , flavivirus , phosphoprotein , biology , cell culture , ns5a , in vitro , viral transformation , hepatitis c virus , phosphorylation , microbiology and biotechnology , hepacivirus , genetics , biochemistry

Human immunodeficiency virus (HIV) load is suppressed during dengue virus infection. The NS5A phosphoprotein of GB virus C (a related flavivirus) inhibits HIV replication in vitro. To determine whether the dengue virus NS5 protein inhibits HIV replication, CD4(+) T cell lines expressing this protein were generated. HIV replication in dengue virus NS5-expressing cells decreased by >90% compared with control cells (P < .01), and this was mediated in part by decreased HIV coreceptor (CXCR4) expression and increased production of SDF-1. Thus, the dengue virus NS5 protein inhibits HIV replication in vitro, potentially explaining the reduction in HIV load observed during acute dengue virus infection.

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