Perinatal Exposure to Antiretroviral Therapy Is Associated with Increased Blood Mitochondrial DNA Levels and Decreased Mitochondrial Gene Expression in Infants | Zendy

Hélène C. F. Côté | Zendy; Janet Raboud | Zendy; Ari Bitnun | Zendy; Ariane Alimenti | Zendy; Deborah Money | Zendy; Evelyn J. Maan | Zendy; Adriana Moldovan Costei | Zendy; Izabelle Gadawski | Zendy; Christina Diong | Zendy; Stanley Read | Zendy; Sandy Shen | Zendy; P. Richard Harrigan | Zendy; David R. Burdge | Zendy; Susan King | Zendy; John C. Forbes | Zendy

Open Access

Perinatal Exposure to Antiretroviral Therapy Is Associated with Increased Blood Mitochondrial DNA Levels and Decreased Mitochondrial Gene Expression in Infants

Author(s) -

Hélène C. F. Côté,

Janet Raboud,

Ari Bitnun,

Ariane Alimenti,

Deborah Money,

Evelyn J. Maan,

Adriana Moldovan Costei,

Izabelle Gadawski,

Christina Diong,

Stanley Read,

Sandy Shen,

P. Richard Harrigan,

David R. Burdge,

Susan King,

John C. Forbes

Publication year - 2008

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/591253

Subject(s) - mitochondrial dna , biology , gene , mitochondrion , gene expression , genetic enhancement , virology , immunology , genetics

The effects of perinatal antiretroviral therapy (ART) on infant mitochondrial function are not well known. We compared blood mitochondrial DNA (mtDNA) levels and mtDNA gene expression (mtRNA) in human immunodeficiency virus (HIV)-uninfected, ART-exposed infants born to HIV-positive mothers with mtDNA levels and mtDNA gene expression in control infants born to uninfected women.

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